丙戊酸所致肝病：1994年至2003年德国新增9例死亡病例
Valproic acid-induced hepatopathy: nine new fatalities in Germany from 1994 to 2003.
作者信息
Koenig Stephan A, Buesing Deike, Longin Elke, Oehring Randi, Häussermann Peter, Kluger Gerhard, Lindmayer Friedemann, Hanusch Ralf, Degen Ingrid, Kuhn Hans, Samii Kamrun, Jungck Albrecht, Brückner Reinhard, Seitz Reinhild, Boxtermann Wolfgang, Weber Yvonne, Knapp Rolf, Richard Hans Helmut, Weidner Birgit, Kasper Johannes-Martin, Haensch Carl-Albrecht, Fitzek Sabine, Hartmann Margarete, Borusiak Peter, Müller-Deile Andrea, Degenhardt Volker, Korenke Georg-Christoph, Hoppen Thomas, Specht Ulrich, Gerstner Thorsten
机构信息
University Children's Hospital Mannheim, Neuropediatric Unit, Mannheim, Germany.
出版信息
Epilepsia. 2006 Dec;47(12):2027-31. doi: 10.1111/j.1528-1167.2006.00846.x.
PURPOSE
Valproic acid (VPA) is an antiepileptic drug (AED) commonly used for generalized and focal epilepsies. We provide an update on hepatotoxic side effects in Germany between 1994 and 2003.
METHODS
We mailed a questionnaire to all members of the German Section of the International League Against Epilepsy, asking for VPA-induced side effects, especially severe side effects such as hepatopathy.
RESULTS
As a result of our questionnaire, we found 31 cases of reversible hepatotoxicity and nine cases of lethal hepatopathies in Germany from 1994 to 2003.
CONCLUSIONS
The outcome of patients with severe hepatotoxicity is better than that in the past. The risk of a VPA-induced hepatopathy is not limited to patients younger than 2 years, receiving polytherapy, or patients with congenital or acquired metabolic diseases.
目的
丙戊酸（VPA）是一种常用于全身性和局灶性癫痫的抗癫痫药物（AED）。我们提供了1994年至2003年德国丙戊酸肝毒性副作用的最新情况。
方法
我们向国际抗癫痫联盟德国分会的所有成员邮寄了一份调查问卷，询问丙戊酸引起的副作用，尤其是严重副作用，如肝病。
结果
根据我们的调查问卷，1994年至2003年在德国发现31例可逆性肝毒性病例和9例致命性肝病病例。
结论
严重肝毒性患者的预后比过去更好。丙戊酸所致肝病的风险并不局限于2岁以下、接受联合治疗或患有先天性或后天性代谢疾病的患者。
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