Lundgren Tobias, Dahl JoAnne, Melin Lennart, Kies Bryan
Department of Psychology, University of Uppsala, Sweden.
Epilepsia. 2006 Dec;47(12):2173-9. doi: 10.1111/j.1528-1167.2006.00892.x.
Psychological interventions in the treatment of epilepsy have been developed and evaluated for many years but the amount of research has hardly made an impact on how epilepsy is treated. The purpose of this study was to develop and evaluate a psychological treatment program consisting of acceptance and commitment therapy (ACT) together with some behavioral seizure control technology shown to be successful in earlier research.
The method consisted of a randomized controlled trial group design with repeated measures (n=27). All participants had an EEG verified epilepsy diagnosis with drug refractory seizures. Participants were randomized into one of two conditions, ACT or supportive therapy (ST). Therapeutic effects were measured by examining changes in quality of life (SWLS and WHOQOL) and seizure index (frequency x duration). Both treatment conditions consisted of only nine hours of professional therapy distributed in two individual and two group sessions during a four-week period.
The results showed significant effects over all of the dependent variables for the ACT group as compared to the ST group at six- and twelve-month follow-ups.
The results from this study suggest that a short-term psychotherapy program combined with anticonvulsant drugs may help to prevent the long-term disability that occurs from drug refractory seizures.
多年来一直在开发和评估用于治疗癫痫的心理干预措施，但研究数量几乎未对癫痫的治疗方式产生影响。本研究的目的是开发和评估一个心理治疗方案，该方案包括接纳与承诺疗法（ACT）以及一些在早期研究中已证明成功的行为性癫痫控制技术。
该方法包括一个重复测量的随机对照试验组设计（n = 27）。所有参与者均经脑电图证实患有癫痫且药物难治性发作。参与者被随机分为两种情况之一，即接受接纳与承诺疗法（ACT）或支持性疗法（ST）。通过检查生活质量（SWLS和WHOQOL）和癫痫发作指数（频率×持续时间）的变化来衡量治疗效果。两种治疗情况均仅包括在四周内分两次个体治疗和两次小组治疗进行的总共九个小时的专业治疗。
结果显示，在六个月和十二个月的随访中，与支持性疗法（ST）组相比，接纳与承诺疗法（ACT）组在所有因变量上均有显著效果。
本研究结果表明，短期心理治疗方案与抗惊厥药物相结合可能有助于预防药物难治性发作导致的长期残疾。
