Azorin J-M, Akiskal H, Akiskal K, Hantouche E, Châtenet-Duchêne L, Gury C, Lancrenon S
Ste Marguerite Hospital, University of Marseilles, Marseilles, France.
Acta Psychiatr Scand. 2007 Jan;115(1):29-34. doi: 10.1111/j.1600-0447.2006.00841.x.
We tested whether factors other than episode severity contributed to psychosis in mania.
Psychiatrists collected systematic clinical data on 1090 hospitalized DSM-IV manic patients in France, and completed the Mania Rating Scale (MRS) and the Scale for the Assessment of Positive Symptoms (SAPS).
Using DSM-IV specifiers, 21.9% were non-severe, 28.2% severe without psychosis, and 49.9% severe with psychosis. On the MRS, patients with psychosis scored significantly higher (P < 0.0001) than non-severe, but did not differ from the severe without psychosis. We found significant correlations between both the Hallucination and the Delusion subscores of the SAPS and the MRS, as well as correlations between age, single marital status, comorbid social phobia and psychotic mania.
Apart from episode severity, social isolation - associated with younger age, single marital status and social phobia - seems to make a contribution to the origin of manic psychosis largely independent from such severity.
我们测试了除发作严重程度之外的其他因素是否会导致躁狂症中的精神病症状。
精神科医生收集了法国1090名住院的DSM-IV躁狂症患者的系统临床数据，并完成了躁狂评定量表（MRS）和阳性症状评定量表（SAPS）。
根据DSM-IV的指定标准，21.9%为非重度，28.2%为重度但无精神病症状，49.9%为重度且有精神病症状。在MRS量表上，有精神病症状的患者得分显著高于非重度患者（P < 0.0001），但与重度无精神病症状的患者无差异。我们发现SAPS的幻觉和妄想子分数与MRS之间存在显著相关性，以及年龄、单身婚姻状况、共病社交恐惧症与精神病性躁狂之间存在相关性。
除发作严重程度外，与年龄较小、单身婚姻状况和社交恐惧症相关的社会隔离似乎在很大程度上独立于这种严重程度，对躁狂性精神病的起源有影响。
