心肌梗死后抑郁患者的ω-3多不饱和脂肪酸状态改变
Altered omega-3 polyunsaturated fatty acid status in depressed post-myocardial infarction patients.
作者信息
Schins A, Crijns H J, Brummer R-J M, Wichers M, Lousberg R, Celis S, Honig A
机构信息
Department of Psychiatry, University Hospital Maastricht, Maastricht, The Netherlands.
出版信息
Acta Psychiatr Scand. 2007 Jan;115(1):35-40. doi: 10.1111/j.1600-0447.2006.00830.x.
OBJECTIVE
Lower levels of long-chain omega-3 polyunsaturated fatty acids (n-3 LCPUFAs) and increased inflammation have been associated with both depressive disorder and myocardial infarction (MI). The present study investigated whether patients who develop depression post-MI, have higher arachidonic acid/eicosapentanoic acid (AA/EPA) ratios than non-depressed post-MI patients and whether depressed post-MI patients have signs of increased inflammation as measured by C-reactive protein (CRP).
METHOD
Serum AA/EPA ratio and plasma CRP levels were quantified in 50 post-MI patients, of which 29 were depressed and 21 non-depressed.
RESULTS
Compared with the non-depressed group, depressed post-MI patients had significantly higher AA/EPA ratios. No significant difference was observed in CRP levels.
CONCLUSION
Depressed post-MI patients had lower levels of n-3 LCPUFAs as measured by mean AA/EPA ratio and no signs of increased inflammation as determined by CRP levels.
目的
长链ω-3多不饱和脂肪酸（n-3 LCPUFAs）水平降低和炎症增加与抑郁症和心肌梗死（MI）均相关。本研究调查了心肌梗死后发生抑郁症的患者，其花生四烯酸/二十碳五烯酸（AA/EPA）比值是否高于心肌梗死后未患抑郁症的患者，以及心肌梗死后抑郁症患者是否有炎症增加的迹象，通过C反应蛋白（CRP）进行测量。
方法
对50例心肌梗死后患者的血清AA/EPA比值和血浆CRP水平进行定量，其中29例患有抑郁症，21例未患抑郁症。
结果
与未患抑郁症组相比，心肌梗死后抑郁症患者的AA/EPA比值显著更高。CRP水平未观察到显著差异。
结论
通过平均AA/EPA比值测量，心肌梗死后抑郁症患者的n-3 LCPUFAs水平较低，且通过CRP水平测定未发现炎症增加的迹象。
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