石英对肺泡巨噬细胞脂质过氧化物的体外作用。

In vitro action of quartz on alveolar macrophage lipid peroxides.

作者信息

Gabor S, Anca Z, Zugravu E

出版信息

Arch Environ Health. 1975 Oct;30(10):499-501. doi: 10.1080/00039896.1975.10666761.

DOI:10.1080/00039896.1975.10666761

PMID:172033

Abstract

The in vitro effects of quartz particles on the lipid peroxide rate were measured on guinea pig pulmonary alveolar macrophages (PAMs). As controls, either PAMs alone or exposed to inert dust were used. The amount of lipid peroxide resulting after one-hour incubation was determined by means of the thiobarbituric acid test (TBA). The results showed that quartz induced a substantial increase of lipid peroxide in PAMs compared with both samples (dust-free or exposed to corundum). The influence of pretreatment of quartz by polyvinylpyridine-N-oxide (PVPNO) and by mineral water containing carbonate and chloride ions was also studied.

摘要

在豚鼠肺泡巨噬细胞（PAM）上测定了石英颗粒对脂质过氧化率的体外影响。作为对照，使用单独的PAM或暴露于惰性粉尘的PAM。通过硫代巴比妥酸试验（TBA）测定孵育一小时后产生的脂质过氧化物量。结果表明，与两个样品（无粉尘或暴露于刚玉）相比，石英诱导PAM中脂质过氧化物大量增加。还研究了用聚乙烯基吡啶-N-氧化物（PVPNO）以及含碳酸根和氯离子的矿泉水对石英进行预处理的影响。