Kluge G, Borte M, Richter T, Kahn T, Borte G
Klinik und Poliklinik für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Leipzig.
Rofo. 2007 Jan;179(1):58-64. doi: 10.1055/s-2006-927302.
To evaluate the quantity and severity of bone disorders in children and adolescents with inflammatory bowel diseases (IBD) and to examine the correlation to whole body growth.
In this study 89 bone mineral density measurements were performed and retrospectively analyzed.
Under consideration of growth retardation, over 65.2 % of the patients with Cohn's disease showed a reduced bone mineral density. Osteopenia/Osteoporosis is seldom seen in patients with ulcerative colitis, i. e., only 34.8 % showed a reduction in bone mineral density. Growth retardation and reduced bone mineral density are correlated. Patients with Cohn's disease and a body length below the 25th height percentile showed a reduced bone mineral density in 78.1 % of the cases. Patients with a body length below the 10th height percentile had a reduced bone mineral density in 83.3 % of the cases.
These results demonstrate the value of osteodensitometric measurements in patients with chronic diseases, especially in children and adolescents with inflammatory bowel disease.
评估炎症性肠病(IBD)患儿及青少年的骨骼疾病数量和严重程度,并研究其与全身生长的相关性。
本研究进行了89次骨密度测量并进行回顾性分析。
考虑到生长发育迟缓,超过65.2%的克罗恩病患者骨密度降低。溃疡性结肠炎患者很少出现骨质减少/骨质疏松,即只有34.8%的患者骨密度降低。生长发育迟缓和骨密度降低相关。身高低于第25百分位数的克罗恩病患者中,78.1%的病例骨密度降低。身高低于第10百分位数的患者中,83.3%的病例骨密度降低。
这些结果证明了骨密度测量在慢性病患者中的价值,尤其是在患有炎症性肠病的儿童和青少年中。