Schulze P, Olechnowitz A F
Arch Exp Veterinarmed. 1975 Jun;29(3):411-25.
The first morphological indication of FMD infection of a cell culture was in the nucleus. Components of nucleoli became segregated and were finally present only as remnants. It was not possible to distinguish different stages of segregation, as in the case of entero-virus infections, because of the rapidity of FMD virus proliferation. Following changes in nucleoli there was margination of chromatin. Particularly striking was an increase in interchromatin granules. Changes in the nuclear membrane seemed to facilitate the transfer of nuclear material to the cytoplasm. Strongly pronounced dilatation of the peri-nuclear cleft, like that seen in aphthae and other tissues, were rarely visible in infected cell cultures.
细胞培养中口蹄疫感染的首个形态学迹象出现在细胞核中。核仁成分开始分离，最终仅以残余物形式存在。由于口蹄疫病毒增殖迅速，无法像肠道病毒感染那样区分不同的分离阶段。核仁发生变化后，染色质出现边缘化。染色质间颗粒的增加尤为显著。核膜的变化似乎有助于核物质向细胞质转移。核周间隙的强烈扩张，如同在口疮及其他组织中所见，在感染的细胞培养物中很少能观察到。
