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0型和亚洲1型口蹄疫病毒在拉齐BHK-21细胞中生长的比较研究。

Comparative studies on growth of foot-and-mouth disease virus types 0 and Asia 1 in BHK-21 Razi cells.

作者信息

Vasantha S, Antony A, Lal S M

出版信息

Acta Virol. 1986 Sep;30(5):367-72.

PMID:2878583
Abstract

Growth pattern of foot-and-mouth disease virus types 0 and Asia 1 in BHK-21 Razi cells was compared; while type 0 virus grew in high titre, Asia 1 virus was produced in low titre. Inhibition of host protein synthesis in type 0 virus-infected cells was more pronounced than in Asia 1 virus-infected cells. Foot-and-mouth disease virus type 0 infected cells showed higher lactic dehydrogenase activity when compared to Asia 1 virus. A significant decrease in virus yield was observed when Actinomycin D had been added at 50 micrograms/ml to infected cells.

摘要

比较了口蹄疫病毒O型和亚洲1型在拉齐BHK - 21细胞中的生长模式；O型病毒高滴度生长，而亚洲1型病毒低滴度产生。O型病毒感染细胞中宿主蛋白合成的抑制比亚洲1型病毒感染细胞中更明显。与亚洲1型病毒相比，口蹄疫病毒O型感染细胞表现出更高的乳酸脱氢酶活性。当向感染细胞中添加50微克/毫升放线菌素D时，观察到病毒产量显著下降。

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