Arca Ercan, Köse Osman, Karslioğlu Yildirim, Taştan Halis Bülent, Demiriz Murat
Department of Dermatology, Gülhane School of Medicine, Ankara, Turkey.
J Dermatol. 2007 Jan;34(1):80-5. doi: 10.1111/j.1346-8138.2007.00222.x.
Eosinophilic cellulitis is characterized clinically by an acute dermatitis resembling cellulitis with unknown etiology. Eosinophilic pustular folliculitis is also a rare inflammatory dermatosis characterized by recurrent crops of erythematous follicular papulopustules that coalesce to form annular plaques with unclear etiopathogenesis. We describe a 20-year-old white male who had vesiculobullous and plaque-like lesions on the hands and feet and was diagnosed with bullous eosinophilic cellulitis clinically and histologically without any etiological agents. Following therapy with oral corticosteroid and oral tetracycline capsules, the lesions disappeared. After a 2-month asymptomatic period, the patient developed pruritic follicular papules and pustules on the lower and upper extremities and upper back. Stool examination revealed Gierdia intestinalis eggs. The patient had complete clearance with treatment of ornidazol for 2 weeks and indomethacin for 2 months. This is the first report of bullous eosinophilic cellulitis coexisting with eosinophilic pustular folliculitis without eosinophilia in the English published work.
嗜酸性蜂窝织炎临床上表现为一种类似蜂窝织炎的急性皮炎,病因不明。嗜酸性脓疱性毛囊炎也是一种罕见的炎症性皮肤病,其特征为反复出现的红斑性毛囊丘疹脓疱,融合形成环形斑块,发病机制尚不清楚。我们描述了一名20岁的白人男性,其手脚出现水疱大疱性和斑块样皮损,临床和组织学诊断为大疱性嗜酸性蜂窝织炎,未发现任何病因。经口服皮质类固醇和口服四环素胶囊治疗后,皮损消失。经过2个月的无症状期后,患者在下肢、上肢和上背部出现瘙痒性毛囊丘疹和脓疱。粪便检查发现肠道鞭毛虫卵。患者经2周奥硝唑和2个月吲哚美辛治疗后完全痊愈。这是英文发表文献中首次报道大疱性嗜酸性蜂窝织炎与嗜酸性脓疱性毛囊炎并存且无嗜酸性粒细胞增多的病例。