Teraki Y, Konohana I, Shiohara T, Nagashima M, Nishikawa T
Department of Dermatology, Hiratsuka City Hospital, Kanagawa, Japan.
Arch Dermatol. 1993 Aug;129(8):1015-9.
Eosinophilic pustular folliculitis is a distinctive dermatosis that was first described in Japan. Although the histopathologic feature of eosinophilic pustular folliculitis is characterized by follicular infiltrates with numerous eosinophils, its pathophysiology remains unclear. The lesional skin of five patients with eosinophilic pustular folliculitis was examined using several monoclonal antibodies including a variety of anti-leukocyte adhesion molecules: endothelial cell adhesion molecule 1, vascular cell adhesion molecule 1, and intercellular adhesion molecule 1, by means of immunohistochemical techniques.
Intercellular adhesion molecule 1 expression by keratinocytes was observed on follicular epithelium, but not on epidermis. The migration of eosinophils and lymphocytes, which were intensely positive for antilymphocyte function-associated antigen 1, was limited to follicular epithelium. Endothelial cell adhesion molecule 1 and vascular cell adhesion molecule 1 expression of vascular endothelium was more often observed around hair follicles. There was no reactivity for interleukin 8 in follicular epithelium.
These findings may explain the selective migration of eosinophils and lymphocytes to the hair follicles in eosinophilic pustular folliculitis.
嗜酸性脓疱性毛囊炎是一种独特的皮肤病，最初在日本被描述。尽管嗜酸性脓疱性毛囊炎的组织病理学特征以毛囊内有大量嗜酸性粒细胞浸润为特点，但其病理生理学仍不清楚。采用免疫组织化学技术，使用包括多种抗白细胞黏附分子（内皮细胞黏附分子1、血管细胞黏附分子1和细胞间黏附分子1）在内的几种单克隆抗体，对5例嗜酸性脓疱性毛囊炎患者的皮损进行了检查。
角质形成细胞表达的细胞间黏附分子1在毛囊上皮可见，但在表皮未见。抗淋巴细胞功能相关抗原1呈强阳性的嗜酸性粒细胞和淋巴细胞的迁移仅限于毛囊上皮。毛囊周围更常观察到血管内皮的内皮细胞黏附分子1和血管细胞黏附分子1表达。毛囊上皮对白介素8无反应性。
这些发现可能解释了嗜酸性脓疱性毛囊炎中嗜酸性粒细胞和淋巴细胞向毛囊的选择性迁移。
