嗜酸性粒细胞性蜂窝织炎（韦尔斯综合征）的诊断与管理：病例系列及文献综述
Diagnosis and management of eosinophilic cellulitis (Wells' syndrome): A case series and literature review.
作者信息
Sinno Hani, Lacroix Jean-Philip, Lee James, Izadpanah Ali, Borsuk Ronnie, Watters Kevin, Gilardino Mirko
机构信息
McGill University, Montreal, Quebec.
出版信息
Can J Plast Surg. 2012 Summer;20(2):91-7. doi: 10.1177/229255031202000204.
INTRODUCTION
Eosinophilic cellulitis (Wells' syndrome) is an inflammatory dermatitis that is often misdiagnosed as infectious cellulitis due to its similarity in presentation. Misdiagnosis leads to delay of correct treatment and inappropriate use of antibiotics.
METHODS
A case series of eosinophilic cellulitis and a literature review are presented.
RESULTS
Patients with Wells' syndrome may present with a variety of nonspecific symptoms, such as fever, arthralgia and malaise, as well as myriad cutaneous lesions with associated erythema, presenting as blisters, bullae, papules and/or nodules. Several treatment modalities have been used to treat eosinophilic cellulitis and have been met with variable success rates; these include systemic corticosteroids, topical corticosteroids and antihistamines, with success rates of 91.7%, 50% and 25%, respectively.
CONCLUSIONS
A high degree of clinical suspicion must be exercised to diagnose this rare condition. Cellulitis with an atypical presentation or not responding to appropriate antibiotic treatment should trigger suspicion of Wells' syndrome. To date, the most successful treatment method is a short course of systemic corticosteroids.
引言
嗜酸性粒细胞性蜂窝织炎（韦尔斯综合征）是一种炎症性皮肤病，因其临床表现相似，常被误诊为感染性蜂窝织炎。误诊会导致正确治疗的延迟以及抗生素的不当使用。
方法
本文介绍了一系列嗜酸性粒细胞性蜂窝织炎病例并进行文献综述。
结果
韦尔斯综合征患者可能出现多种非特异性症状，如发热、关节痛和不适，以及伴有红斑的多种皮肤损害，表现为水疱、大疱、丘疹和/或结节。已采用多种治疗方法来治疗嗜酸性粒细胞性蜂窝织炎，成功率各不相同；这些方法包括全身性皮质类固醇、局部皮质类固醇和抗组胺药，成功率分别为91.7%、50%和25%。
结论
诊断这种罕见疾病时必须高度怀疑。非典型表现的蜂窝织炎或对适当抗生素治疗无反应的情况应引发对韦尔斯综合征的怀疑。迄今为止，最成功的治疗方法是短期使用全身性皮质类固醇。
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