氯化锂诱导疾病后大鼠脑中C-fos的表达
C-fos expression in the rat brain following lithium chloride-induced illness.
作者信息
St Andre Justin, Albanos Katie, Reilly Steve
机构信息
Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, USA.
出版信息
Brain Res. 2007 Mar 2;1135(1):122-8. doi: 10.1016/j.brainres.2006.12.010. Epub 2007 Jan 3.
Abstract
The present study examined c-Fos expression in selected brain areas consequent to administration of lithium chloride, the typical illness-inducing agent used in laboratory studies of conditioned taste aversion. The results replicated previous findings of significant c-Fos expression in the parabrachial nucleus, the central nucleus of the amygdala and the basolateral amygdala. New findings indicate significant lithium-induced c-Fos in the gustatory region of the thalamus and the bed nucleus of the stria terminalis but not in the insular cortex. The results are discussed with respect to the neural substrates of conditioned taste aversion.
摘要
本研究检测了给予氯化锂后特定脑区的c-Fos表达，氯化锂是在条件性味觉厌恶实验室研究中常用的典型致病症剂。结果重复了先前在臂旁核、杏仁核中央核和杏仁核基底外侧核中发现的显著c-Fos表达。新发现表明，氯化锂可在丘脑味觉区和终纹床核中诱导显著的c-Fos表达，但在岛叶皮质中则不然。针对条件性味觉厌恶的神经基质对结果进行了讨论。
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