Brauers J, Kresken M, Menke A, Orland A, Weiher H, Morrissey I
Antiinfectives Intelligence GmbH, Von-Liebig-Strasse 20, 53359 Rheinbach, Germany.
Int J Antimicrob Agents. 2007 Mar;29(3):322-5. doi: 10.1016/j.ijantimicag.2006.10.003. Epub 2007 Jan 3.
The bactericidal activities of daptomycin, vancomycin, teicoplanin and linezolid at human peak free serum concentrations (C(max,free)) were determined against Staphylococcus aureus (one methicillin-susceptible and two methicillin-resistant strains), Enterococcus faecalis and Enterococcus faecium (one vancomycin-susceptible and one vancomycin-resistant strain of each). Daptomycin was rapidly bactericidal against 7/7 strains at C(max,free) of 22.0 mg/L (corresponding to 63% protein binding) and against 3/7 strains at 4.8 mg/L (corresponding to 92% protein binding). Vancomycin (18.0 mg/L) was bactericidal against only two strains. Both teicoplanin (4.5 mg/L) and linezolid (10.4 mg/L) were consistently bacteriostatic. Daptomycin is a useful option for the treatment of Gram-positive infections owing to its strong bactericidal activity.
测定了达托霉素、万古霉素、替考拉宁和利奈唑胺在人血清游离峰浓度（C(max,free)）下对金黄色葡萄球菌（一株甲氧西林敏感菌株和两株甲氧西林耐药菌株）、粪肠球菌和屎肠球菌（各一株万古霉素敏感菌株和一株万古霉素耐药菌株）的杀菌活性。达托霉素在C(max,free)为22.0 mg/L（对应63%的蛋白结合率）时对7/7株菌株具有快速杀菌作用，在4.8 mg/L（对应92%的蛋白结合率）时对3/7株菌株具有快速杀菌作用。万古霉素（18.0 mg/L）仅对两株菌株具有杀菌作用。替考拉宁（4.5 mg/L）和利奈唑胺（10.4 mg/L）均始终表现为抑菌作用。由于达托霉素具有强大的杀菌活性，它是治疗革兰氏阳性菌感染的一个有用选择。
