流式细胞术作为一种工具，用于确定细胞壁活性抗生素对万古霉素敏感和耐药粪肠球菌菌株的影响。
Flow cytometry as a tool to determine the effects of cell wall-active antibiotics on vancomycin-susceptible and -resistant Enterococcus faecalis strains.
机构信息
EA3964, Faculté de Médecine Xavier Bichat, Université Paris 7, Paris, France.
出版信息
Antimicrob Agents Chemother. 2011 Jan;55(1):395-8. doi: 10.1128/AAC.00970-10. Epub 2010 Oct 18.
Abstract
Flow cytometry and confocal microscopy were used to study the effects of vancomycin, daptomycin, telavancin, and PA1409, a new investigational vancomyquine, on the morphology, membrane potential, and permeability of glycopeptide-susceptible and -resistant Enterococcus faecalis strains. Daptomycin exerted the most pronounced effects on bacterial size and bacterial permeability against susceptible and resistant strains.
摘要
流式细胞术和共聚焦显微镜用于研究万古霉素、达托霉素、替拉凡星和 PA1409（一种新型研究用万古霉素类似物）对糖肽敏感性和耐药性粪肠球菌形态、膜电位和通透性的影响。达托霉素对敏感和耐药菌株的细菌大小和细菌通透性的影响最为显著。
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