Haak Robert M, Tarabiono Chiara, Janssen Dick B, Minnaard Adriaan J, de Vries Johannes G, Feringa Ben L
Department of Organic and Molecular Inorganic Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
Org Biomol Chem. 2007 Jan 21;5(2):318-23. doi: 10.1039/b613937j. Epub 2006 Dec 11.
3-Alkenyl and heteroaryl chloroalcohols have been obtained in excellent enantiomeric excess (>99%) by enzymatic kinetic resolution using the haloalcohol dehalogenase HheC. Yields were close to the theoretical maximum for all substrates employed. Furthermore, the applicability of this methodology on multigram scale has been established.
