甘草对雷公藤治疗类风湿关节炎的减毒增效作用
[Toxicity attenuation and efficacy potentiation effect of liquorice on treatment of rheumatoid arthritis with Tripterygium wilfordii].
作者信息
Li Ya-Song, Tong Pei-Jian, Ma Hong-Zhen
机构信息
Zhejiang Provincial Hospital of TCM, Hangzhou.
出版信息
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Dec;26(12):1117-9.
OBJECTIVE
To investigate the toxicity attenuation and efficacy potentiation effect of liquorice on treatment of rheumatoid arthritis (RA) with Tripterygium wilfordii (TW).
METHODS
One hundred and twenty RA patients were randomly assigned to two groups: the treated group treated with compound decoctum of TW and liquorice and the control group with TW ployglycosidium tablets both based on routine treatment. The therapeutic effect and adverse reaction were observed after 2 months of treatment.
RESULTS
The total efficacy rate was 89.8% in the treated group and 79.6% in the control group with insignificant difference between the two groups; the effect was better in the treated group than that of the control group in decreasing the swollen joint index and increasing the average grip strength of both hands (P < 0.05); the total incidence of adverse reaction was obviously lower in the treated group than that of the control (P < 0.01).
CONCLUSION
Liquorice has toxicity attenuation and efficacy potentiation effect on treatment of RA with TW.
目的
探讨甘草对雷公藤治疗类风湿关节炎（RA）的减毒增效作用。
方法
将120例RA患者随机分为两组：治疗组采用雷公藤与甘草复方煎剂治疗，对照组采用雷公藤多苷片治疗，两组均在常规治疗基础上用药。治疗2个月后观察疗效及不良反应。
结果
治疗组总有效率为89.8%，对照组为79.6%，两组差异无统计学意义；治疗组在降低关节肿胀指数及增加双手平均握力方面疗效优于对照组（P<0.05）；治疗组不良反应总发生率明显低于对照组（P<0.01）。
结论
甘草对雷公藤治疗RA具有减毒增效作用。
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