Su D, Song Y, Li R
Hubei Academy of Traditional Chinese Medicine and Pharmacy, Wuhan.
Zhong Xi Yi Jie He Za Zhi. 1990 Mar;10(3):144-6, 131.
It was satisfactory using the ethyl acetate extract of Tripterygium wilfordii (TW) to treat rheumatoid arthritis (RA). The results showed that the ethyl acetate extract of TW was the effective component part of TW. Although the therapeutic effect of 15 cases with RA cured by triptolide was as effective as the ethyl acetate extract of TW, triptolide could impair some patients' hearts. This suggested that triptolide was one of the main effective elements of TW, but it was also one of the main toxic elements. Clinical research indicated that: (1) the effect of TW in treating RA was the synergistic action of elements with triptolide as the main; (2) triptolide may act as a major standard of controlling the quality of the preparation of TW and assure clinical use safely.
使用雷公藤（TW）的乙酸乙酯提取物治疗类风湿性关节炎（RA）效果良好。结果表明，TW的乙酸乙酯提取物是TW的有效组成部分。虽然雷公藤甲素治愈的15例RA患者的治疗效果与TW的乙酸乙酯提取物相同，但雷公藤甲素会损害一些患者的心脏。这表明雷公藤甲素是TW的主要有效成分之一，但也是主要有毒成分之一。临床研究表明：（1）TW治疗RA的效果是以雷公藤甲素为主的多种成分协同作用的结果；（2）雷公藤甲素可作为控制TW制剂质量的主要指标，以确保临床安全用药。
