Du X, Zhang H, Fu X
Affiliated Hospital of Shandong Traditional Chinese Medical University, Jinan 250011.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1998 Feb;18(2):88-91.
To observe the curative effect, toxic and side effect of Tripterygium Wilfordii Complex Ester Tablet (TWT, a preparation of Folium Tripterygium wilfordii) in treating rheumatoid arthritis.
Two hundred and seventy seven patients were observed with prospective, multicentric and random double-blind control method. One hundred and forty cases of TWT group were treated with TWT 2 tablets each time, 3 times a day orally, and the other 137 cases treated with Tripterygium Wilfordii Polycoside Tablet (TPT, a preparation of Radix Tripterygium Wilfordii) 2 tablets each time were taken as control, 3 times a day orally. The therapeutic course for both groups was 6 weeks.
The markedly controlled rate of the TWT group was 26.71% and the total effective rate was 86.43%, while those in the control group were 26.28% and 83.94% respectively, the difference between the two groups was insignificant (P > 0.05). The occurrence of side-effect in the two groups was 20.00% and 23.35% respectively, also showed no significant difference (P > 0.05).
The Folium Tripterygium Wilfordii preparation is similar in efficacy and security to the Radix Tripterygium Wilfordii preparation.
观察雷公藤复合酯片（雷公藤叶制剂）治疗类风湿关节炎的疗效、毒副作用。
采用前瞻性、多中心、随机双盲对照法观察277例患者。雷公藤复合酯片组140例，每次口服2片，每日3次；另137例服用雷公藤多苷片（雷公藤根制剂）作为对照，每次2片，每日3次口服。两组疗程均为6周。
雷公藤复合酯片组显控率为26.71%，总有效率为86.43%；对照组显控率为26.28%，总有效率为83.94%，两组比较差异无统计学意义（P＞0.05）。两组不良反应发生率分别为20.00%和23.35%，差异无统计学意义（P＞0.05）。
雷公藤叶制剂与雷公藤根制剂疗效和安全性相似。
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