Niogi Sumit N, Mukherjee Pratik, McCandliss Bruce D
Sackler Institute for Developmental Psychobiology, Weill Cornell Medical College, 1300 York Avenue, Box 140, New York, NY 10021, USA.
Neuroimage. 2007 Mar;35(1):166-74. doi: 10.1016/j.neuroimage.2006.10.040. Epub 2007 Jan 4.
Reproducible Objective Quantification Scheme (ROQS) is a novel method for regional white matter measurements of diffusion tensor imaging (DTI) parameters that overcomes the limitations of previous approaches for analyzing large cohorts of subjects reliably. ROQS is a semi-automated technique that exploits the fiber orientation information from the diffusion tensor in conjunction with a binary masking and chain-linking algorithm to segment anatomically distinct white matter tracts for subsequent quantitative analysis of DTI parameters such as fractional anisotropy and apparent diffusion coefficient. When applied to 3-T whole-brain DTI of normal adult volunteers, ROQS is shown to segment the corpus callosum much faster than manual region of interest (ROI) delineation, and with better reproducibility and accuracy.
可重复客观量化方案（ROQS）是一种用于扩散张量成像（DTI）参数区域白质测量的新方法，它克服了以往可靠分析大量受试者方法的局限性。ROQS是一种半自动技术，它利用扩散张量中的纤维取向信息，结合二元掩膜和链连接算法，对解剖学上不同的白质束进行分割，以便随后对DTI参数（如分数各向异性和表观扩散系数）进行定量分析。当应用于正常成年志愿者的3-T全脑DTI时，ROQS分割胼胝体的速度比手动感兴趣区域（ROI）描绘快得多，并且具有更好的可重复性和准确性。
