Wakana Setsu, Caprihan Arvind, Panzenboeck Martina M, Fallon James H, Perry Michele, Gollub Randy L, Hua Kegang, Zhang Jiangyang, Jiang Hangyi, Dubey Prachi, Blitz Ari, van Zijl Peter, Mori Susumu
F. M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute Baltimore, MD 21205, USA.
Neuroimage. 2007 Jul 1;36(3):630-44. doi: 10.1016/j.neuroimage.2007.02.049. Epub 2007 Mar 20.
Tractography based on diffusion tensor imaging (DTI) allows visualization of white matter tracts. In this study, protocols to reconstruct eleven major white matter tracts are described. The protocols were refined by several iterations of intra- and inter-rater measurements and identification of sources of variability. Reproducibility of the established protocols was then tested by raters who did not have previous experience in tractography. The protocols were applied to a DTI database of adult normal subjects to study size, fractional anisotropy (FA), and T2 of individual white matter tracts. Distinctive features in FA and T2 were found for the corticospinal tract and callosal fibers. Hemispheric asymmetry was observed for the size of white matter tracts projecting to the temporal lobe. This protocol provides guidelines for reproducible DTI-based tract-specific quantification.
基于扩散张量成像(DTI)的纤维束成像能够实现对白质纤维束的可视化。在本研究中,描述了重建11条主要白质纤维束的方案。这些方案通过评估者内部和评估者之间的多次测量迭代以及变异性来源的识别进行了完善。然后,由之前没有纤维束成像经验的评估者对既定方案的可重复性进行了测试。这些方案应用于成人正常受试者的DTI数据库,以研究各个白质纤维束的大小、分数各向异性(FA)和T2值。在皮质脊髓束和胼胝体纤维的FA和T2值中发现了显著特征。投射到颞叶的白质纤维束大小存在半球不对称性。该方案为基于DTI的可重复纤维束特异性量化提供了指导原则。