Münch G, Raether A, Schöffel E, Illes P
Department of Pharmacology, University of Freiburg, F.R.G.
J Cardiovasc Pharmacol. 1991 Sep;18(3):468-71. doi: 10.1097/00005344-199109000-00021.
Changes in the external diameter of rabbit isolated jejunal arteries were measured by a photoelectric device. Both norepinephrine and dopamine produced vasoconstriction; prazosin, but not idazoxan, antagonized these effects. Arteries preconstricted with norepinephrine were dilated by SKF 38393 and LY 171555. SCH 23390 antagonized both compounds, however, in the case of LY 171555 with a lower potency. Sulpiride also interacted with LY 171555. When arteries were preconstricted with PGF2 alpha in the presence of prazosin, idazoxan, and propranolol, SKF 38393 caused vasodilation, while LY 171555 and dopamine were inactive. We conclude that in jejunal arteries both DA1- and DA2-receptors may be present at the vascular smooth muscle.
采用光电装置测量兔离体空肠动脉的外径变化。去甲肾上腺素和多巴胺均引起血管收缩；哌唑嗪可拮抗这些作用，而异唑嗪则不能。用去甲肾上腺素预收缩的动脉可被SKF 38393和LY 171555舒张。然而，SCH 23390可拮抗这两种化合物，不过对LY 171555的拮抗作用较弱。舒必利也与LY 171555相互作用。当动脉在哌唑嗪、异唑嗪和普萘洛尔存在的情况下用前列腺素F2α预收缩时，SKF 38393引起血管舒张，而LY 171555和多巴胺则无活性。我们得出结论，在空肠动脉的血管平滑肌中可能同时存在DA1和DA2受体。
