Balmforth A J, Lyall F, Morton J I, Ball S G
Department of Biochemistry, University of Glasgow, U.K.
Eur J Pharmacol. 1988 Oct 18;155(3):305-8. doi: 10.1016/0014-2999(88)90519-5.
Incubation of cultured mesenteric vascular smooth muscle cells with dopamine, in the presence of propranolol, caused an increase in cyclic AMP formation in a concentration-dependent manner (Ka apparent 6.8 +/- 0.5 microM). This effect of dopamine was inhibited by the DA1-receptor antagonist SCH 23390 (Ki = 1 nM). These results suggest that cultured mesenteric vascular smooth muscle cells express DA1-receptors linked to adenylate cyclase.
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