Grabarczyk M, Woźniak J, Podstawka U, Kopeć-Szlezak J
Department of Physiopathology, Institute of Haematology, Warszawa, Poland.
Mater Med Pol. 1990 Jul-Sep;22(3):184-7.
After lindane administration in daily doses of 0.1 LD50 for one month (total dose 2.0 LD50) changes in the erythrocytes were found persisting for up to 4 months after withdrawal of the pesticide. A significant increase in the number of echinocytes, a greater per cent of reticulocytes, significantly raised level of denatured haemoglobin, and an increased number of erythrocytes of higher sensitivity to oxidating factors in relation to control group was observed.
在以每日剂量0.1 LD50给予林丹一个月(总剂量2.0 LD50)后,发现红细胞的变化在停用该农药后持续长达4个月。与对照组相比,棘红细胞数量显著增加、网织红细胞百分比更高、变性血红蛋白水平显著升高,以及对氧化因子敏感性更高的红细胞数量增加。