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地塞米松联合化疗治疗犬淋巴瘤的II期临床试验

Phase II clinical trial of combination chemotherapy with dexamethasone for lymphoma in dogs.

作者信息

Greenberg Chelsea B, Boria Pedro A, Borgatti-Jeffreys Antonella, Raskin Rose E, Lucroy Michael D

机构信息

Department of Veterinary Clinical Sciences, Purdue University, 625 Harrison Street, West Lafayette, Indiana 47907, USA.

出版信息

J Am Anim Hosp Assoc. 2007 Jan-Feb;43(1):27-32. doi: 10.5326/0430027.

DOI:10.5326/0430027
PMID:17209082
Abstract

Dogs with histologically confirmed lymphoma were treated with a 14-week induction chemotherapy protocol that included dexamethasone. A phase II clinical trial was done using a standard two-stage design. Complete remission occurred in 21 (88%) dogs, with a median initial progression-free interval of 186 days. Toxicity was mild and self-limiting in the majority of dogs.

摘要

组织学确诊为淋巴瘤的犬只接受了为期14周的诱导化疗方案,该方案包括地塞米松。采用标准的两阶段设计进行了一项II期临床试验。21只(88%)犬只实现完全缓解,初始无进展生存期的中位数为186天。大多数犬只的毒性轻微且为自限性。

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引用本文的文献

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Early progression during or after cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy indicates poor outcome with rescue protocols in dogs with multicentric lymphoma.在接受环磷酰胺、多柔比星、长春新碱和泼尼松化疗期间或之后早期进展的多中心淋巴瘤犬采用挽救方案预后不良。
J Vet Intern Med. 2024 Jul-Aug;38(4):2282-2292. doi: 10.1111/jvim.17139. Epub 2024 Jul 3.
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Alternating Rabacfosadine/Doxorubicin: Efficacy and Tolerability in Naïve Canine Multicentric Lymphoma.交替使用拉巴福沙定/多柔比星:初治犬多中心淋巴瘤的疗效和耐受性
J Vet Intern Med. 2017 May;31(3):872-878. doi: 10.1111/jvim.14700. Epub 2017 Apr 3.