地塞米松联合化疗治疗犬淋巴瘤的II期临床试验
Phase II clinical trial of combination chemotherapy with dexamethasone for lymphoma in dogs.
作者信息
Greenberg Chelsea B, Boria Pedro A, Borgatti-Jeffreys Antonella, Raskin Rose E, Lucroy Michael D
机构信息
Department of Veterinary Clinical Sciences, Purdue University, 625 Harrison Street, West Lafayette, Indiana 47907, USA.
出版信息
J Am Anim Hosp Assoc. 2007 Jan-Feb;43(1):27-32. doi: 10.5326/0430027.
Dogs with histologically confirmed lymphoma were treated with a 14-week induction chemotherapy protocol that included dexamethasone. A phase II clinical trial was done using a standard two-stage design. Complete remission occurred in 21 (88%) dogs, with a median initial progression-free interval of 186 days. Toxicity was mild and self-limiting in the majority of dogs.
组织学确诊为淋巴瘤的犬只接受了为期14周的诱导化疗方案，该方案包括地塞米松。采用标准的两阶段设计进行了一项II期临床试验。21只（88%）犬只实现完全缓解，初始无进展生存期的中位数为186天。大多数犬只的毒性轻微且为自限性。
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