Nakamura T, Ide H, Eguchi R, Nogami A, Endo T, Hanashi T, Kubota N, Hayashi K, Yoshida K, Hanyu F
Dept. of Surgery, Tokyo Women's Medical College.
Gan To Kagaku Ryoho. 1991 Dec;18(15):2573-9.
We report clinico-pathological studies on the effect of preoperative hyperthermia and chemotherapy combined with radiotherapy (HCR) for progress of the local curability of advanced esophageal carcinoma. The subjects of these studies were 17 patients who underwent subtotal esophagectomy after preoperative irradiation 40 Gy from 1980 to 1989, of which 8 patients had HCR, 6 patients irradiation only (R), 3 patients both irradiation and chemotherapy (CR). The clinical response rate of the patients with R or CR was 33% (PR 3, MR 3, NC 3), and the histological effective (Ef3 or Ef2) rate was 56% (Ef3 1, Ef2 4, Ef1 4). The clinical response rate of the patients with HCR was 88% (PR 7, MR 1), and the histological effective rate was 100% (Ef3 1 Ef2 7). HCR was more effective than R or CR for the local lesion of esophageal carcinoma histopathologically (p less than 0.05). However, the survival rate of patients with HCR was similar to R and CR, respectively. These results suggest that further improvement of the heating methods and the methods of combining hyperthermia with irradiation and chemotherapy is needed.
我们报告了关于术前热疗、化疗联合放疗（HCR）对晚期食管癌局部治愈率进展影响的临床病理研究。这些研究的对象是1980年至1989年间接受40Gy术前放疗后行食管次全切除术的17例患者，其中8例接受HCR，6例仅接受放疗（R），3例接受放疗和化疗（CR）。R或CR组患者的临床缓解率为33%（PR 3例，MR 3例，NC 3例），组织学有效（Ef3或Ef2）率为56%（Ef3 1例，Ef2 4例，Ef1 4例）。HCR组患者的临床缓解率为88%（PR 7例，MR 1例），组织学有效率为100%（Ef3 1例，Ef2 7例）。在食管癌局部病变的组织病理学方面，HCR比R或CR更有效（p＜0.05）。然而，HCR组患者的生存率分别与R组和CR组相似。这些结果表明，需要进一步改进加热方法以及热疗与放疗和化疗联合的方法。
