Wnt/平面细胞极性信号在晶状体纤维细胞分化过程中起作用吗？
A role for Wnt/planar cell polarity signaling during lens fiber cell differentiation?
作者信息
Chen Y, Stump R J W, Lovicu F J, McAvoy J W
机构信息
Save Sight Institute, The University of Sydney, NSW, Australia.
出版信息
Semin Cell Dev Biol. 2006 Dec;17(6):712-25. doi: 10.1016/j.semcdb.2006.11.005. Epub 2006 Nov 19.
Abstract
Wnt signaling through frizzled (Fz) receptors plays key roles in just about every developmental system that has been studied. Several Wnt-Fz signaling pathways have been identified including the Wnt/planar cell polarity (PCP) pathway. PCP signaling is crucial for many developmental processes that require major cytoskeletal rearrangements. Downstream of Fz, PCP signaling is thought to involve the GTPases, Rho, Rac and Cdc42 and regulation of the JNK cascade. Here we report on the localization of these GTPases and JNK in the lens and assess their involvement in the cytoskeletal reorganisation that is a key element of FGF-induced lens fiber cell differentiation.
摘要
通过卷曲蛋白（Fz）受体进行的Wnt信号传导在几乎所有已研究的发育系统中都起着关键作用。已经确定了几种Wnt-Fz信号通路，包括Wnt/平面细胞极性（PCP）通路。PCP信号传导对于许多需要主要细胞骨架重排的发育过程至关重要。在Fz的下游，PCP信号传导被认为涉及GTP酶、Rho、Rac和Cdc42以及JNK级联反应的调节。在这里，我们报告了这些GTP酶和JNK在晶状体中的定位，并评估了它们在细胞骨架重组中的作用，而细胞骨架重组是FGF诱导的晶状体纤维细胞分化的关键要素。
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