系统性红斑狼疮患者的听觉前庭功能障碍
Audiovestibular disturbance in patients with systemic lupus erythematosus.
作者信息
Karatas Erkan, Onat Ahmet Mesut, Durucu Cengiz, Baglam Tekin, Kanlikama Muzaffer, Altunoren Orcun, Buyukhatipoglu Hakan
机构信息
Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey.
出版信息
Otolaryngol Head Neck Surg. 2007 Jan;136(1):82-6. doi: 10.1016/j.otohns.2006.06.1255.
OBJECTIVE
The aim of this study was to evaluate the audiovestibular disturbance in patients with systemic lupus erythematosus (SLE).
STUDY DESIGN AND SETTING
Twenty-eight patients with SLE and 28 healthy control subjects were included. Pure-tone audiometry, impedance audiometry, and electronystagmography (ENG) were used for baseline evaluation. Laboratory tests were carried out. Cranial and brain stem magnetic resonance imagings (MRI) were undertaken.
RESULTS
Nineteen (67%) patients reported audiovestibular symptoms. Sensorineural hearing loss was found in 6 (21%) patients. Abnormal results on ENG were significantly higher (50%) (P < 0.01). Abnormal laboratory data were available from 26 patients (P < 0.05). MRI did not show any pathosis.
CONCLUSION
The audiovestibular disturbances in SLE are more prevalent than previously recognized. Although no cause and effect relationship can be established by this type of study, it appears that a relationship exists.
SIGNIFICANCE
Audiologic research should be directed toward routine, pure tone audiometry, and ENG assessment for patients with SLE to enable crucial treatment.
目的
本研究旨在评估系统性红斑狼疮（SLE）患者的视听前庭功能障碍。
研究设计与设置
纳入28例SLE患者和28例健康对照者。采用纯音听力测定、声阻抗测听和眼震电图（ENG）进行基线评估。进行实验室检查。进行头颅和脑干磁共振成像（MRI）。
结果
19例（67%）患者报告有视听前庭症状。6例（21%）患者发现感音神经性听力损失。ENG异常结果显著更高（50%）（P<0.01）。26例患者有异常实验室数据（P<0.05）。MRI未显示任何病变。
结论
SLE患者的视听前庭功能障碍比以前认识到的更为普遍。虽然这类研究无法建立因果关系，但似乎存在某种关联。
意义
听力研究应针对SLE患者进行常规纯音听力测定和ENG评估，以便进行关键治疗。
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