Dysphagia in patients with frontotemporal lobar dementia.

BACKGROUND

Hyperorality, compulsive eating and aspiration because of food gorging, has been described in patients with frontotemporal lobar dementia (FTLD), but swallowing function in this population has not been reported.

OBJECTIVE

To identify the swallowing status in a sample of patients with FTLD.

DESIGN

Case series.

SETTING

Referral center, ambulatory care.

PATIENTS

A consecutive series of referred patients with 3 variants of FTLD were asked to participate. Twenty-one patients were enrolled, including 9 with frontotemporal dementia, 7 with progressive nonfluent aphasia, and 5 with semantic dementia.

INTERVENTION

The patients underwent a fiberoptic endoscopic examination of swallowing to assess their ability to swallow liquids and food.

MAIN OUTCOME MEASURES

Presence of dysphagia and nature of impaired swallowing.

RESULTS

Of the 21 patients, 4 caretakers reported swallowing difficulties. An instrumental examination revealed moderate swallowing abnormalities in 12 of the 21 patients. These abnormalities were not explained by compulsive eating behaviors, but seemed to reflect deficits in cortical and subcortical pathways connecting with the brainstem swallowing center.

CONCLUSIONS

When assessed via instrumentation, swallowing abnormalities are found in many patients with FTLD. The appearance of dysphagia signals progression of FTLD to brainstem systems.