感冒药中的去甲麻黄碱与出血性中风风险
Phenylpropanolamine contained in cold remedies and risk of hemorrhagic stroke.
作者信息
Yoon B W, Bae H J, Hong K S, Lee S M, Park B J, Yu K H, Han M K, Lee Y S, Chung D K, Park J M, Jeong S W, Lee B C, Cho K H, Kim J S, Lee S H, Yoo K M
机构信息
Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, 110-744, Republic of Korea.
出版信息
Neurology. 2007 Jan 9;68(2):146-9. doi: 10.1212/01.wnl.0000250351.38999.f2.
In this study, we sought to elucidate whether phenylpropanolamine (PPA) in cold remedies (small and divided doses) increases the risk of hemorrhagic stroke (HS). PPA exposure significantly increased the risk, and the risk was much higher in women. In women, linear trends were also found in recency, duration, and dosage of PPA exposure. PPA contained in cold remedies increases the risk of HS, particularly in women.
在本研究中，我们试图阐明感冒药中（小剂量且分次服用）的苯丙醇胺（PPA）是否会增加出血性中风（HS）的风险。接触PPA会显著增加风险，且女性的风险更高。在女性中，还发现了PPA接触的近期性、持续时间和剂量方面的线性趋势。感冒药中含有的PPA会增加HS的风险，尤其是在女性中。
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