Malik M, Camm A J
Department of Cardiological Sciences, St. George's Hospital Medical School, London, England.
Pacing Clin Electrophysiol. 1991 Nov;14(11 Pt 1):1648-71. doi: 10.1111/j.1540-8159.1991.tb02741.x.
This article is the second part of a three article series reviewing computer simulation models of the heart, in particular of cardiac electrophysiology. The previous section of the review discussed the methodological principles of the construction and application of computer models. This article overviews the development of mathematical and computer modeling studies applied to cardiology. The models are classified according to the physiological processes that were simulated; this article distinguishes models oriented to cardiac mechanics, hemodynamics, and electrophysiology. The electrophysiology models are discussed in more detail and the review classifies them into four main categories: models of cellular processes, models of tissue behavior, models of the ventricular electric field, and models of macroconduction disturbances. In each category, the historical development of the models and their key achievements are described.
本文是三篇系列文章的第二篇，该系列文章回顾了心脏的计算机模拟模型，特别是心脏电生理学模型。综述的上一部分讨论了计算机模型构建和应用的方法学原理。本文概述了应用于心脏病学的数学和计算机建模研究的发展。这些模型根据所模拟的生理过程进行分类；本文区分了针对心脏力学、血液动力学和电生理学的模型。电生理学模型将进行更详细的讨论，综述将它们分为四个主要类别：细胞过程模型、组织行为模型、心室电场模型和宏观传导障碍模型。在每个类别中，都描述了模型的历史发展及其关键成就。
