米索前列醇在孕早期和孕中期稽留流产病例中的联合应用。
Combined administration of misoprostol in the first and second trimester missed abortion cases.
作者信息
Kutlu T, Tuğrul S, Aran T, Uslu H, Eren S, Oral O
机构信息
Zeynep Kamil Women and Children's Education and Research Hospital, Istanbul, Turkey.
出版信息
Clin Exp Obstet Gynecol. 2006;33(4):226-8.
OBJECTIVE
We aimed to investigate the effectiveness and adverse effects of combined (vaginal + oral) administration of misoprostol in missed abortion cases.
MATERIAL AND METHODS
48 missed abortion cases between 8 and 20 weeks of gestation were enrolled in this study. Misoprostol-induced medical abortion was planned; the first dose (200 microg) was administered intravaginally and subsequent doses (200 microg each) orally every following hour. A maximum of six doses (1200 microg) were used. Revision curettage was performed on all subjects who aborted.
RESULTS
The mean time interval from the first dose of misoprostol until the abortion was 6.27 +/- 3.02 hours. The success rate was 95% for the whole group. We observed misoprostol-related trembling in one patient and fever in two patients.
CONCLUSION
We believe that our low-dose combined misoprostol protocol is a safe, effective and well-tolerated method with minimal adverse effects for the termination of both first and second trimester pregnancy losses.
目的
我们旨在研究米索前列醇阴道加口服联合给药在稽留流产病例中的有效性及不良反应。
材料与方法
本研究纳入了48例妊娠8至20周的稽留流产病例。计划采用米索前列醇药物流产；首剂（200微克）经阴道给药，随后每小时口服给药（每次200微克）。最多使用六剂（1200微克）。对所有流产的受试者进行刮宫术。
结果
从首剂米索前列醇给药至流产的平均时间间隔为6.27±3.02小时。全组成功率为95%。我们观察到1例患者出现与米索前列醇相关的震颤，2例患者出现发热。
结论
我们认为，我们的低剂量米索前列醇联合用药方案是一种安全、有效且耐受性良好的方法，对终止孕早期和孕中期流产的不良反应最小。
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