Yoshida Shin, Hazama Shoichi, Kondo Hiroshi, Sakamoto Kazuhiko, Tamesa Takao, Ueno Tomio, Oka Masaaki
Dept. of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine.
Gan To Kagaku Ryoho. 2006 Nov;33(12):1845-7.
We examined retrospectively the efficacy of hepatic arterial infusion (HAI) chemotherapy comparing systemic treatment as adjuvant therapy after the curative resection of hepatic metastasis from colorectal cancer. Seventeen cases of HAI and 8 of the systemic treatment were enrolled in this study. We compared the pattern of recurrent sites and the overall survival rate between the two groups. There was no difference in a patients' background. Intrahepatic recurrence rate was lower and extrahepatic recurrence rate was higher in the HAI group, but not significant. The 1-, 3-, and 5-year overall survival rate was 94, 72, and 49% in the HAI group and 100, 100, and 50% in the systemic treatment group (p = 0.29), respectively. HAI chemotherapy did not contribute to the elongation of survival time in comparison with systemic treatment. This study indicates that there is no efficacy of HAI alone after the resection of hepatic metastasis from colorectal cancer and that there is need to use systemic chemotherapy together with HAI to prevent an extrahepatic recurrence.
我们回顾性研究了肝动脉灌注（HAI）化疗作为结直肠癌肝转移根治性切除术后辅助治疗与全身治疗相比的疗效。本研究纳入了17例接受HAI治疗的患者和8例接受全身治疗的患者。我们比较了两组患者的复发部位模式和总生存率。两组患者的背景无差异。HAI组肝内复发率较低，肝外复发率较高，但差异无统计学意义。HAI组1年、3年和5年总生存率分别为94%、72%和49%，全身治疗组分别为100%、100%和50%（p = 0.29）。与全身治疗相比，HAI化疗对延长生存时间并无作用。本研究表明，结直肠癌肝转移切除术后单独使用HAI无效，需要将全身化疗与HAI联合使用以预防肝外复发。
