Meng Sheng, Maragakis Paul, Papaloukas Costas, Kaxiras Efthimios
Department of Physics and Division of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA.
Nano Lett. 2007 Jan;7(1):45-50. doi: 10.1021/nl0619103.
We investigate the interaction of individual DNA nucleosides with a carbon nanotube (CNT) in vacuum and in the presence of external gate voltage. We propose a scheme to discriminate between nucleosides on CNTs based on measurement of electronic features through a local probe such as scanning tunneling spectroscopy. We demonstrate through quantum mechanical calculations that these measurements can achieve 100% efficiency in identifying DNA bases. Our results support the practicality of ultrafast DNA sequencing using electrical measurements.
我们研究了单个DNA核苷与碳纳米管（CNT）在真空中以及存在外部栅极电压时的相互作用。我们提出了一种基于通过局部探针（如扫描隧道光谱）测量电子特征来区分碳纳米管上核苷的方案。我们通过量子力学计算证明，这些测量在识别DNA碱基方面可以达到100%的效率。我们的结果支持了使用电学测量进行超快速DNA测序的实用性。
