Chambers S A, Charman S C, Rahman A, Isenberg D A
MRCP, The Centre for Rheumatology, University College London Hospital, 250 Euston Road, 3rd Floor Central, London NW1 2PG, UK.
Ann Rheum Dis. 2007 Sep;66(9):1173-7. doi: 10.1136/ard.2006.062984. Epub 2007 Jan 9.
To determine the prevalence of other autoimmune diseases (AID) in black, Caucasian and South Asian patients with systemic lupus erythematosus (SLE) compared with the prevalence of these AID in the UK population, and to assess the impact of these additional AID on damage scores and mortality.
The prevalence and chronology of development of additional AID in SLE patients was determined by case note review. Comparisons were made with prevalence data for AID in the general UK population. The impact of additional AID on mortality and damage scores at up to 10 years was determined in the index cases (patients who developed another AID either in the same year or within 5 years of onset of SLE) compared with controls matched for sex, age, ethnicity and year of onset of SLE.
There was no significant difference in the total number of AID that developed in patients from each ethnic group but differences in the frequency of some AID were noted. Mortality and damage scores were worse at 5 years in the study cases than the controls, particularly in the peripheral vascular category.
Patients with SLE might develop other AID that could complicate management of SLE by having an adverse impact on damage scores and mortality.
确定黑人、白人和南亚系统性红斑狼疮（SLE）患者中其他自身免疫性疾病（AID）的患病率，并与英国人群中这些AID的患病率进行比较，同时评估这些额外的AID对损伤评分和死亡率的影响。
通过病例记录回顾确定SLE患者中额外AID的患病率和发病时间顺序。与英国普通人群中AID的患病率数据进行比较。在指数病例（即在同一年或SLE发病后5年内发生另一种AID的患者）中，与性别、年龄、种族和SLE发病年份相匹配的对照组相比，确定额外AID对长达10年的死亡率和损伤评分的影响。
各民族患者发生的AID总数无显著差异，但某些AID的发生频率存在差异。研究病例在5年时的死亡率和损伤评分比对照组更差，尤其是在外周血管方面。
SLE患者可能会发生其他AID，这些AID可能会对损伤评分和死亡率产生不利影响，从而使SLE的管理复杂化。
