Bouchard Charles S, John Thomas
Department of Ophthalmology, Loyola University Medical Center, Maywood, Illinois 60153, USA.
Ocul Surf. 2004 Jul;2(3):201-11. doi: 10.1016/s1542-0124(12)70062-9.
Since 1995, with the availability of cryopreserved amniotic membrane (AM), the use of AM as a patch or graft for ocular surface reconstruction has become recognized as an important alternative for treatment of persistent epithelial defects and sterile ulceration that are refractory to conventional therapy. A major problem with evaluating the efficacy of AM transplantation is the lack of controlled clinical studies. Moreover, for some diseases there is no accepted "standard" therapy, and the incidence of the disease is too low to allow proper randomization. In this review, we have attempted to assess the indications and outcomes of AM transplantation based on 661 cases reported in the peer-reviewed literature. Successful outcome was defined as the healing of an epithelial defect (corneal or conjunctival) over a specified time period and the lack of induced motility disturbance.
自1995年以来，随着冷冻保存羊膜（AM）的可得性，羊膜作为眼表重建的贴片或移植物，已被公认为是治疗传统疗法难以治愈的持续性上皮缺损和无菌性溃疡的重要替代方法。评估羊膜移植疗效的一个主要问题是缺乏对照临床研究。此外，对于某些疾病，没有公认的“标准”疗法，而且疾病发病率过低，无法进行适当的随机分组。在本综述中，我们试图根据同行评审文献中报道的661例病例评估羊膜移植的适应证和结果。成功的结果定义为上皮缺损（角膜或结膜）在特定时间段内愈合，且未引起运动障碍。
