Kruse F E, Rohrschneider K, Völcker H E
Universitäts-Augenklinik Heidelberg.
Ophthalmologe. 1998 Feb;95(2):114-9. doi: 10.1007/s003470050247.
Persistent defects of the ocular surface remain a therapeutic challenge that often requires surgical intervention. Recently, the transplantation of human amniotic membrane has been added to our therapeutic armentarium. This thick basement membrane has distinct biological properties that influence cellular differentiation and proliferation. Amniotic membrane obtained from cesarean deliveries is prepared and cryopreserved under sterile conditions and can be sutured onto the ocular surface. This procedure allows for reepithelialization of persistent corneal ulcerations as well as filling of stromal defects. Amniotic membrane can successfully be employed for ocular surface reconstruction following large corneal excisions and in the context of limbal stem cell disease for pterygium surgery as well as for various kinds of reconstruction of the conjunctiva. Taken together, amniotic membrane transplantation can serve as a valuable tool for ocular surface reconstruction, especially in the context of impaired epithelial function.
眼表的持续性缺损仍然是一个治疗难题，常常需要手术干预。最近，人羊膜移植已被纳入我们的治疗手段。这种厚厚的基底膜具有独特的生物学特性，会影响细胞分化和增殖。从剖宫产获取的羊膜在无菌条件下制备并冷冻保存，可缝合到眼表。该手术可使持续性角膜溃疡重新上皮化，并填充基质缺损。羊膜移植能成功用于大的角膜切除术后的眼表重建，以及在翼状胬肉手术的角膜缘干细胞疾病背景下，还可用于结膜的各种重建。总之，羊膜移植可作为眼表重建的一种有价值的工具，尤其是在上皮功能受损的情况下。
