Stenbæk Dea Siggaard, Dam Vibeke Høyrup, Fisher Patrick MacDonald, Hansen Nanna, Hjordt Liv Vadskjær, Frokjaer Vibe Gedsoe
Neurobiology Research Unit, the Neuroscience Centre, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Center for Integrated Molecular Brain Imaging and Center for Experimental Medicine Neuropharmacology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
PLoS One. 2017 Sep 7;12(9):e0184403. doi: 10.1371/journal.pone.0184403. eCollection 2017.
Serotonin (5-HT) brain architecture appears to be implicated in normal personality traits as supported by genetic associations and studies using molecular brain imaging. However, so far, no studies have addressed potential contributions to variation in normal personality traits from in vivo serotonin 4 receptor (5-HT4R) brain availability, which has recently become possible to image with Positron Emission Tomography (PET). This is particularly relevant since availability of 5-HT4R has been shown to adapt to synaptic levels of 5-HT and thus offers information about serotonergic tone in the healthy brain. In 69 healthy participants (18 females), the associations between personality traits assessed with the five-factor NEO Personality Inventory-Revised (NEO PI-R) and regional cerebral 5-HT4R binding in neocortex, amygdala, hippocampus, and anterior cingulate cortex (ACC) were investigated using linear regression models. The associations between each of the five personality traits and a latent variable construct of global 5-HT4R levels were also evaluated using latent variable structural equation models. We found no significant associations between the five NEO personality traits and regional 5-HT4R binding (all p-values > .17) or the latent construct of global 5-HT4R levels (all p-values > .37). Our findings indicate that NEO personality traits and 5-HT4R are not related in healthy participants. Under the assumption that global 5-HT4R levels index 5-HT tone, our data also suggest that 5-HT tone per se is not directly implicated in normal personality traits.
血清素（5-羟色胺，5-HT）脑结构似乎与正常人格特质有关，这一点得到了基因关联研究以及使用分子脑成像技术的研究所支持。然而，到目前为止，尚无研究探讨活体血清素4受体（5-HT4R）脑可利用性对正常人格特质变异的潜在贡献，而正电子发射断层扫描（PET）技术最近已使对其进行成像成为可能。这一点尤为重要，因为已证明5-HT4R的可利用性会适应5-HT的突触水平，从而提供有关健康大脑中血清素能张力的信息。在69名健康参与者（18名女性）中，使用线性回归模型研究了用五因素修订版NEO人格量表（NEO PI-R）评估的人格特质与新皮层、杏仁核、海马体和前扣带回皮质（ACC）中区域脑5-HT4R结合之间的关联。还使用潜在变量结构方程模型评估了五种人格特质中的每一种与全球5-HT4R水平的潜在变量结构之间的关联。我们发现，五种NEO人格特质与区域5-HT4R结合（所有p值>.17）或全球5-HT4R水平的潜在结构（所有p值>.37）之间均无显著关联。我们的研究结果表明，在健康参与者中，NEO人格特质与5-HT4R无关。假设全球5-HT4R水平可反映5-HT张力，我们的数据还表明，5-HT张力本身与正常人格特质无直接关联。
