Amikishieva A V, Ovsiukova M V
Ross Fiziol Zh Im I M Sechenova. 2006 Oct;92(10):1212-20.
Effects of dehydroepiandrosterone-sulfate (10, 30 and 100 microg/kg, i.p.) on stability of sexual motivation of C57BL/6J male mice with different psychoemotional statuses were studied. Sexual motivation was assessed for 30 min in the sensory contact setting: a male was exposed to a female at oestrus from behind a perforated transparent partition which prevented physical contact. In the intact males, dehydroepiandrosterone-sulfate injection (10 and 30 microg/kg) 4 hrs before the test had no effect on parameters of sexual motivation. In aggressive males, administration of the dehydroepiandrosterone-sulfate had no effect on the intensity of the initial 10 min phase of sexual motivation but prevented its rapid decrease afterwards. In submissive mice, either dose reduced intensity of the initial phase of behavioral reaction to receptive female; however, tile higher dose prevented motivation from exhaustion, and so interest to the female was persistent, albeit decreased. The highest dose of dehydroepiandrosterone-sulfate had inhibitory effects on stability of the sexual interest in the male mice of all experimental groups.
研究了硫酸脱氢表雄酮（10、30和100微克/千克，腹腔注射）对不同心理情绪状态的C57BL/6J雄性小鼠性动机稳定性的影响。在感官接触环境中评估30分钟的性动机：将一只雄性小鼠隔着有孔的透明隔板暴露于处于发情期的雌性小鼠面前，隔板可防止身体接触。在未受刺激的雄性小鼠中，在测试前4小时注射硫酸脱氢表雄酮（10和30微克/千克）对性动机参数没有影响。在攻击性雄性小鼠中，给予硫酸脱氢表雄酮对性动机最初10分钟阶段的强度没有影响，但可防止其随后迅速下降。在顺从性小鼠中，两种剂量均降低了对处于发情期雌性小鼠行为反应初始阶段的强度；然而，较高剂量可防止动机耗尽，因此对雌性小鼠的兴趣持续存在，尽管有所降低。最高剂量的硫酸脱氢表雄酮对所有实验组雄性小鼠的性兴趣稳定性具有抑制作用。
