Hamans Bob C, Barth Markus, Leenders William P, Heerschap Arend
Department of Radiology, Radboud University Medical Centre, Nijmegen, The Netherlands.
Z Med Phys. 2006;16(4):269-74. doi: 10.1078/0939-3889-00325.
Susceptibility weighted imaging (SWI) has been introduced as a novel approach to visualize the venous vasculature in the human brain. With SWI, small veins in the brain are depicted based on the susceptibility difference between deoxyhaemoglobin in the veins and surrounding tissue, which is further enhanced by the use of MR phase information. In this study we applied SWI in the mouse brain using an exogenous iron-based blood-pool contrast agent, with the aims of further enhancing the susceptibility effect and allowing the visualization of individual veins and arteries. Contrast enhanced (CE-) SWI of the brain was performed on healthy mice and mice carrying intracerebral glioma xenografts. This study demonstrates that detailed vascular information in the mouse brain can be obtained by using CE-SWI and is substantially enhanced compared to native SWI (i.e. without contrast agent). CE-SWI images of tumour-bearing mice were directly compared to histology, confirming that CE-SWI depicts the vessels supplying and draining the tumour. We propose that CE-SWI is a very promising tool for the characterization of tumour vasculature.
磁化率加权成像（SWI）已作为一种可视化人类大脑静脉血管系统的新方法被引入。通过SWI，大脑中的小静脉基于静脉中脱氧血红蛋白与周围组织之间的磁化率差异得以描绘，利用磁共振相位信息可进一步增强这种差异。在本研究中，我们使用一种外源性铁基血池造影剂在小鼠大脑中应用SWI，目的是进一步增强磁化率效应并实现对单个静脉和动脉的可视化。对健康小鼠和携带脑内胶质瘤异种移植瘤的小鼠进行了大脑对比增强（CE-）SWI检查。本研究表明，通过使用CE-SWI可获得小鼠大脑中详细的血管信息，且与天然SWI（即不使用造影剂）相比有显著增强。将荷瘤小鼠的CE-SWI图像直接与组织学进行比较，证实CE-SWI描绘了为肿瘤供血和引流的血管。我们认为CE-SWI是一种用于表征肿瘤血管系统的非常有前景的工具。
