Hussein N G, Saad A A, Hashem S A, El-Sewedy S M
Department of Applied Medical Chemistry, Medical Research Institute, Alexandria University, Egypt.
J Egypt Public Health Assoc. 1998;73(5-6):691-705.
The activities of renal phenolsulfotransferase and arylsulfatases A and B were estimated in 400 male Swiss albino mice classified into four groups: Normal controls, Schistosoma mansoni infected group, Dimethylnitrosamine (DMN) treated group and infected treated group. The activity levels of the studied enzymes were significantly increased in all groups when compared with the control group, also the statistical analyses showed a high significant increase of the three enzymes levels in the infected treated group; when compared separately with treated or infected groups. It was concluded, therefore, that schistosomal infection is implicated in the development of kidney cancer which may arise from the pattern of hepatic mixed-function oxidase induction characterized for schistosomiasis and its temporal relationship with the procarcinogenic initiating events. Furthermore, the striking significant increase in the enzymatic activity levels of the acid hydrolases arylsulfatases due to the lesion of both cytotoxic effects of dimethylnitrosamine as well as pathological change of schistosomiasis which may play an active role in the initiation of the malignant process by detoxifying endogenous sulfated aromatic metabolites.
对400只雄性瑞士白化小鼠的肾酚磺基转移酶以及芳基硫酸酯酶A和B的活性进行了评估，这些小鼠被分为四组：正常对照组、曼氏血吸虫感染组、二甲基亚硝胺（DMN）处理组和感染处理组。与对照组相比，所有组中所研究酶的活性水平均显著升高，统计分析还表明，在感染处理组中这三种酶的水平有极显著升高；与单独的处理组或感染组相比也是如此。因此得出结论，血吸虫感染与肾癌的发生有关，这可能源于血吸虫病所特有的肝混合功能氧化酶诱导模式及其与致癌起始事件的时间关系。此外，由于二甲基亚硝胺的细胞毒性作用以及血吸虫病的病理变化导致酸性水解酶芳基硫酸酯酶的酶活性水平显著升高，这可能通过对内源性硫酸化芳香族代谢产物进行解毒在恶性过程的起始中发挥积极作用。
