Jacobson D A, Philipson L H
Department of Medicine-Endocrinology Section, University of Chicago, 5841 S Maryland Ave, Chicago, IL, USA.
Handb Exp Pharmacol. 2007(179):409-24. doi: 10.1007/978-3-540-34891-7_24.
Orchestrated ion fluctuations within pancreatic islets regulate hormone secretion and maybe essential to processes such as apoptosis. A diverse set of ion channels allows for islet cells to respond to a variety of signals and dynamically regulate hormone secretion and glucose homeostasis (reviewed by Houamed et al. 2004). This chapter focuses on transient receptor potential (TRP)-related channels found within the beta cells of the islet and reviews their roles in both insulin secretion and apoptosis.
胰岛内精心编排的离子波动调节激素分泌，可能对诸如细胞凋亡等过程至关重要。各种各样的离子通道使胰岛细胞能够对多种信号作出反应，并动态调节激素分泌和葡萄糖稳态（Houamed等人，2004年综述）。本章重点关注胰岛β细胞中发现的与瞬时受体电位（TRP）相关的通道，并综述它们在胰岛素分泌和细胞凋亡中的作用。
