瞬时受体电位香草酸亚型（TRPV）通道与肥大细胞功能之间的联系。

Link between TRPV channels and mast cell function.

作者信息

Turner H, del Carmen K A, Stokes A

机构信息

Center for Biomedical Research at Queen's Medical Center, University Tower 811, 1356 Lusitana Street, Honolulu, HI 96813, USA.

出版信息

Handb Exp Pharmacol. 2007(179):457-71. doi: 10.1007/978-3-540-34891-7_27.

DOI:10.1007/978-3-540-34891-7_27

PMID:17217073

Abstract

Mast cells are tissue-resident immune effector cells. They respond to diverse stimuli by releasing potent biological mediators into the surrounding tissue, and initiating inflammatory responses that promote wound healing and infection clearance. In addition to stimulation via immunological routes, mast cells also respond to polybasic secretagogues and physical stimuli. Each mechanism for mast cell activation relies on the influx of calcium through specific ion channels in the plasma membrane. Recent reports suggest that several calcium-permeant cation channels of the TRPV family are expressed in mast cells. TRPV channels are a family of sensors that receive and react to chemical messengers and physical environmental cues, including thermal, osmotic, and mechanical stimuli. The central premise of this review is that TRPVs transduce physiological and pathophysiological cues that are functionally coupled to calcium signaling and mediator release in mast cells. Inappropriate mast cell activation is at the core of numerous inflammatory pathologies, rendering the mast cell TRPV channels potentially important therapeutic targets.

摘要

肥大细胞是驻留在组织中的免疫效应细胞。它们通过向周围组织释放强效生物介质，并引发促进伤口愈合和感染清除的炎症反应，来对多种刺激做出反应。除了通过免疫途径进行刺激外，肥大细胞还对多碱性促分泌素和物理刺激做出反应。肥大细胞激活的每种机制都依赖于钙通过质膜上特定离子通道的内流。最近的报告表明，TRPV家族的几种钙通透阳离子通道在肥大细胞中表达。TRPV通道是一类感受器，可接收化学信使和物理环境线索并做出反应，包括热、渗透压和机械刺激。本综述的核心前提是，TRPVs转导与肥大细胞中的钙信号传导和介质释放功能偶联的生理和病理生理线索。肥大细胞的不适当激活是众多炎症性疾病的核心，这使得肥大细胞TRPV通道可能成为重要的治疗靶点。