Lavrent'eva A V, Mel'nikova V I, Sapronova A Ia, Proshliakova E V, Voronova S N, Ugriumov M V
Ross Fiziol Zh Im I M Sechenova. 2006 Aug;92(8):975-83.
This study was aimed to test our hypothesis that dopamine synthesized in the neurons of the brain is delivered to the general circulation in rats during prenatal and early postnatal periods, i.e. before the establishment of the blood-brain barrier. Using the high performance liquid chromatography, it was demonstrated that the dopamine concentration and content in the peripheral blood in fetuses and neonatal rats (i.e. before the establishment of the blood-brain barrier) greatly exceeded those in adult rats. Moreover, the establishment of the blood-brain barrier was accompanied by the significant increase of the dopamine concentration in the brain. A drop of the dopamine concentration in fetal plasma after the microsurgical lesion of the forebrain and mesencephalon (encephalectomy) are considered as direct evidence in favour of our hypothesis.
本研究旨在验证我们的假设，即在产前和产后早期，即血脑屏障建立之前，大鼠大脑神经元中合成的多巴胺会进入体循环。使用高效液相色谱法证明，胎儿和新生大鼠（即血脑屏障建立之前）外周血中的多巴胺浓度和含量大大超过成年大鼠。此外，血脑屏障的建立伴随着大脑中多巴胺浓度的显著增加。前脑和中脑显微手术损伤（脑切除术）后胎儿血浆中多巴胺浓度的下降被视为支持我们假设的直接证据。
