Gu Yanlong, Ogawa Chikako, Kobayashi Shū
Graduate School of Pharmaceutical Sciences, The University of Tokyo, The HFRE Division, ERATO, Japan Science and Technology Agency, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Org Lett. 2007 Jan 18;9(2):175-8. doi: 10.1021/ol062446b.
A neutral catalytic system for Michael reactions of indoles has been developed by combining silica-supported benzenesulfonic acid sodium salt with hydrophobic ionic liquid in water. An efficient hydrophobic environment could be created on the surface of the silica-sodium material under the conditions. Various indole derivatives and alpha,beta-unsaturated carbonyl compounds including some acid-labile substrates were successfully applied to this system with water as the sole solvent to afford the desired Michael adducts in high yields. [structure: see text].
通过将二氧化硅负载的苯磺酸钠盐与疏水性离子液体在水中相结合，开发出了一种用于吲哚迈克尔反应的中性催化体系。在此条件下，可在二氧化硅-钠材料表面形成高效的疏水环境。各种吲哚衍生物和α,β-不饱和羰基化合物，包括一些对酸不稳定的底物，都成功应用于该体系，以水作为唯一溶剂，高产率地得到了所需的迈克尔加成物。[结构：见原文]
