Watanabe Hideaki, Takano Masashi, Umino Akinori, Ito Toshiya, Ishikawa Hiroyuki, Nakada Masahisa
Department of Chemistry, Faculty of Science and Engineering, Waseda University, 3-4-1, Ohkubo, Shinjuku, Tokyo 169-8555, Japan.
Org Lett. 2007 Jan 18;9(2):359-62. doi: 10.1021/ol0628816.
The first enantioselective total synthesis of (-)-erinacine B has been achieved. Our approach features convergent construction of the 5-6-7 tricyclic cyathane core system via chiral building blocks prepared using asymmetric catalysis developed by us and highly stereoselective construction of all stereogenic centers in the aglycon. [reaction: see text].
已完成（-）-erinacine B的首次对映选择性全合成。我们的方法特点是通过使用我们开发的不对称催化制备的手性砌块汇聚构建5-6-7三环紫杉烷核心体系，并在苷元中高立体选择性地构建所有立体中心。[反应：见正文]
