通过分子内 Pauson-Khand 反应的 (+)-fusarisetin A 的不对称全合成。
Asymmetric total synthesis of (+)-fusarisetin A via the intramolecular Pauson-Khand reaction.
机构信息
Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.
出版信息
Org Lett. 2013 Aug 2;15(15):4018-21. doi: 10.1021/ol401831w. Epub 2013 Jul 19.
An asymmetic total synthesis of (+)-fusarisetin A has been achieved. The essential to our strategy was the application of the intramolecular Pauson-Khand reaction for the stereoselective construction of the trans-decalin subunit of (+)-fusarisetin A with a unique C16 quarternary chiral center. The developed chemistry offers an alternative to the IMDA reaction that has been used for fusarisetin A, and is applicable to analogue synthesis for biological evaluation.
（+）- fusarisetin A 的不对称全合成已经实现。我们策略的关键是应用分子内 Pauson-Khand 反应，以立体选择性的方式构建（+）- fusarisetin A 的反式十氢萘亚基，其中具有独特的 C16 季碳手性中心。所开发的化学方法为已经用于 fusarisetin A 的 IMDA 反应提供了替代方案，并且适用于类似物合成以进行生物评估。
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