Khoury J, Henriksen T, Seljeflot I, Mørkrid L, Frøslie K F, Tonstad S
Department of Obstetrics and Gynaecology, Rikshospitalet-Radiumhospitalet Medical Centre, Oslo, Norway.
BJOG. 2007 Mar;114(3):279-88. doi: 10.1111/j.1471-0528.2006.01187.x.
To study the effect of an antiatherogenic diet on maternal and cord blood concentrations of systemic biomarkers of endothelial cell activation, haemostasis and inflammation.
Single blinded randomised controlled clinical trial.
Obstetric outpatient clinic and maternity unit of a university hospital in Norway.
Nonsmoking pregnant women aged 21-38 years carrying a single fetus and with no previous pregnancy-related complications.
Subjects (n = 290) were randomised to continue their usual diet or to adopt a diet low in saturated fat and cholesterol from gestational week 17-20 to birth. Soluble forms of cellular adhesion molecules, high-sensitivity C-reactive protein (CRP) and haemostatic markers were measured at 17-20 weeks of gestation (baseline) and subsequently up to week 36. All the above, except CRP, were also measured in cord blood.
Concentrations of maternal and fetal biomarkers and maternal CRP.
All biomarkers except CRP levels increased significantly during the study period in both the intervention and control groups. None of the maternal or fetal biomarkers were influenced by the intervention (P > 0.05) except for a tendency to lower concentrations of cord blood tissue plasminogen activator antigen in the intervention group compared with the control group, median (interquartile range) 5.4 ng/ml (3.1-7.7) versus 5.8 ng/ml (3.5-11.8), P = 0.05.
An antiatherogenic diet in pregnancy did not significantly influence maternal or fetal blood concentrations of a range of biomarkers for inflammation. Thus, the previously reported effects of a cholesterol-lowering diet on maternal lipid profile and preterm delivery (<37 complete weeks of gestation) do not seem to involve changes in the systemic inflammatory responses of pregnancy.
研究抗动脉粥样硬化饮食对母体及脐带血中内皮细胞活化、止血和炎症相关系统生物标志物浓度的影响。
单盲随机对照临床试验。
挪威一所大学医院的产科门诊和产科病房。
年龄在21 - 38岁、单胎妊娠且既往无妊娠相关并发症的非吸烟孕妇。
将290名受试者随机分为两组，一组继续其常规饮食，另一组从妊娠第17 - 20周直至分娩采用低饱和脂肪和胆固醇饮食。在妊娠17 - 20周（基线）时测量细胞黏附分子的可溶性形式、高敏C反应蛋白（CRP）和止血标志物，随后直至36周进行随访测量。除CRP外，上述所有指标也在脐带血中进行测量。
母体和胎儿生物标志物的浓度以及母体CRP。
在研究期间，干预组和对照组中除CRP水平外的所有生物标志物均显著升高。除干预组脐带血组织纤溶酶原激活物抗原浓度有低于对照组的趋势外（中位数（四分位间距）分别为5.4 ng/ml（3.1 - 7.7）和5.8 ng/ml（3.5 - 11.8），P = 0.05），母体或胎儿的生物标志物均未受干预影响（P > 0.05）。
孕期抗动脉粥样硬化饮食对一系列炎症生物标志物的母体或胎儿血液浓度无显著影响。因此，先前报道的降低胆固醇饮食对母体血脂谱和早产（妊娠<37整周）的影响似乎并不涉及孕期全身炎症反应的改变。
