Sotelo C, Alvarado-Mallart R M
Laboratory of Neuromorphology, INSERM U 106, Hôpital de la Salpétrière, France.
Trends Neurosci. 1991 Aug;14(8):350-5. doi: 10.1016/0166-2236(91)90161-m.
Repair of adult 'point-to-point' systems by neural grafting is possible only when grafted neurons succeed in synaptically replacing the host's missing neurons, thus re-establishing the anatomical and functional integrity of the impaired circuits. Grafting experiments carried out on the cerebellum of the adult pcd (Purkinje-cell-degeneration) mutant mouse (an animal model of hereditary degenerative ataxia) reveal that embryonic Purkinje cells, by some unknown sorting mechanism, selectively invade the deprived cerebellar cortex. These neurons migrate to their proper domains and, inducing axonal sprouting of specific populations of host neurons, they become integrated synaptically within the pcd cerebellar cortex. However, the re-establishment of the corticonuclear projection is achieved only rarely, and this is the current experimental limit for the complete reconstruction of the cerebellar circuit.
只有当移植的神经元成功地通过突触替代宿主缺失的神经元，从而重新建立受损回路的解剖和功能完整性时，成年“点对点”系统的神经移植修复才有可能。在成年pcd（浦肯野细胞变性）突变小鼠（遗传性退行性共济失调的动物模型）的小脑上进行的移植实验表明，胚胎浦肯野细胞通过某种未知的分选机制，选择性地侵入缺失浦肯野细胞的小脑皮质。这些神经元迁移到它们的适当区域，并诱导宿主神经元特定群体的轴突发芽，它们在pcd小脑皮质内通过突触整合。然而，皮质核投射的重建很少能实现，这是目前小脑回路完全重建的实验极限。
