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[肝素与癌症]

[Heparin and cancer].

作者信息

Lykke Jakob

机构信息

H:S Bispebjerg Hospital, Kirurgisk Gastroenterologisk Afdeling K, København NV.

出版信息

Ugeskr Laeger. 2006 Dec 11;168(50):4397-401.

Abstract

The association between cancer and venous thromboembolism is well described. Several studies indicate that elements of the haemostatic system participate in tumour genesis. During the last decade a number of post-hoc analyses of trials not primarily designed to evaluate the effect of low molecular weight heparins (LMWH), on cancer survival, have indicated an increased survival. This has recently been supported by results from several prospective trials with LMWH. The possible anti-cancer effect of LMWH is not known in details. Treatment regimes with LMWH have to be performed.

摘要

癌症与静脉血栓栓塞之间的关联已得到充分描述。多项研究表明,止血系统的成分参与肿瘤发生。在过去十年中,一些并非主要旨在评估低分子量肝素(LMWH)对癌症生存影响的试验事后分析表明生存率有所提高。最近,几项使用LMWH的前瞻性试验结果也支持了这一点。LMWH可能的抗癌作用尚不清楚。必须实施LMWH治疗方案。

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