结核分枝杆菌H37Rv1中碳水化合物代谢途径

Pathways of carbohydrate metabolism in mycobacterium tuberculosis H37Rv1.

作者信息

Jayanthi Bai N, Ramachandra Pai M, Suryanarayana Murthy P, Venkitasubramanian T A

出版信息

Can J Microbiol. 1975 Nov;21(11):1688-91. doi: 10.1139/m75-247.

Abstract

Radiorespirometric studies using glucose labelled at 1, 2, 3-4, and 6 positions and enzymatic studies were conducted to determine the primary pathways of glucose dissimilation in Mycobacterium tuberculosis H37Rv. The pattern of 14CO2 recovery was C3-4 greater than C1 greater than C6 = C2. The Embden-Meyerhof pathway was found to be the predominant pathway for glucose oxidation, operative to the extent of 94%. The pentose phosphate pathway accounted for the remaining 6%. Maximum incorporation of 14C into cellular components was from C2 and C6 labelled glucose.

摘要

使用在1、2、3 - 4和6位标记葡萄糖的放射呼吸测定研究以及酶学研究，以确定结核分枝杆菌H37Rv中葡萄糖异化的主要途径。14CO2回收模式为C3 - 4大于C1大于C6 = C2。发现糖酵解途径是葡萄糖氧化的主要途径，其作用程度达94%。磷酸戊糖途径占其余的6%。14C最大程度掺入细胞成分是来自C2和C6标记的葡萄糖。